Compared to other biomarkers, NT-proBNP is the strongest independent predictor of in-hospital and 180-day mortality. In NSTE-ACS, NT-proBNP adds substantial information to the TIMI risk score and the ACC/AHA classification. NT-proBNP was not an independent predictor of risk of new myocardial infarction, even in the acute or long term. Conclusions: The extent score added to the TIMI risk score improves the prognostic value of the latter in patients with NSTEMI. 001), and added significant prognostic information to the TIMI and ACC/AHA prognostic categories. 001) and 180-day mortality (OR 1.67, 95% CI: 1.41-1.99, p <. The GRACE risk score requires 8 variables to assess risk of in-hospital mortality, as follows: age, heart rate, systolic blood pressure, Killip classification. Adjusting by clinical, ECG variables, and biomarkers, NT-proBNP concentration was the strongest independent predictor of in-hospital (OR 1.7, 95% CI: 1.31-2.20, p <. Mean RR and SDNN show a perfect linear relationship (r = 0.657, p < 0.001).Ĭonclusion: It was observed that depressed heart rate variability and increased 24-hours mean heart rate correlates with high TIMI risk score after acute ST-elevation myocardial infarction.We prospectively studied the additive value of N-terminal probrain natriuretic peptide (NT-proBNP) in relation to the Thrombolysis in Myocardial Infarction (TIMI) risk score and the American College of Cardiology/American Heart Association (ACC/AHA) joint prognostic classification, and compared the predictive capacity of NT-proBNP, troponin T (TnT), C-reactive protein (hsCRP), myoglobin, and creatine kinase-MB (CK-MB) concentrations in a cohort of 1483 consecutive patients with non-ST-segment-elevation acute coronary syndromes (NSTE-ACS).Ĭentralised measurements of NT-proBNP, TnT, myoglobin, and hsCRP were performed 3 h (median) after admission. High TIMI risk score also showed a negative correlation with mean RR interval (r=-574, p<0.001). There was a significant correlation between depressed SDNN and high TIMI risk score (r=.893, p=.001). Among the TIMI risk groups SDNN values were 120.0 ± 19, 871.0 ± 20.5 and 40.9 ± 6.4 msec in mild, moderate and high risk group respectively(p=<0.001). % between 0 – 2 and 24% 8 or more than 8.SDNN and RR interval stratified by TIMI risk score demonstrates that both the variables decreases significantly with the increase of TIMI risk score. The TIMI risk score was developed to predict the occurrence of a composite endpoint (all-cause mortality, myocardial infarction, or urgent revascularisation) at.
Stratification of subjects by TIMI risk score shows that nearly 60% had risk score in the range of 3 – 7, 17. Results : Ninety one patients (mean age 53.9 ± 10.8 years), 86.7% were males and 14( mean age 59.8 ± 8.8 years), 13.3% were female. SDNN for HRV and mean RR interval for mean heart rate were recorded. TIMI risk score were calculated and each patient under went 24hour Holter monitoring. Total 105 STEMI patients were included in the study. Methods: This study was conducted in NICVD (National Institute of Cardiovascular Diseases), Dhaka, from July 2008 to June 2009. Correlation among these factors has not been studied thoroughly. Interestingly, the TIMI risk score makes no use of continuous variables such as blood pressure (BP) and heart rate. TIMI risk score, Heart rate variability, STEMI Abstractīackground: Thrombolysis In Myocardial Infarction (TIMI) risk score, heart rate variability (HRV) and 24hour mean heart rate all are important predictor of prognosis after ST segment elevation myocardial infarction(STEMI).
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